Recognize limits of evidence and avoid overstatement

The manuals converge on a clear caution about overstatement. Across the extracts, the sources recommend presenting findings as preliminary or experimental, not as established treatment efficacy, and they repeatedly note the limits of open-label or small-sample evidence. Several extracts also converge on the need to acknowledge that replication in controlled trials is still required, especially where placebo control or randomisation is absent. They also agree that methodological limits matter for how effects are communicated. The sources mention small sample size, lack of placebo or control groups, open-label design, and unanswered questions about mechanisms or generalisability. In that sense, the manuals frame responsible communication as closely tied to transparency about what the data can and cannot support. The main differences are in emphasis. The ayahuasca extracts focus more on preliminary, uncontrolled evidence and the risk of therapeutic misconception, while the LSD-assisted psychotherapy extract gives more explicit attention to the absence of a long-term control group and to uncertainty about mechanisms. One ayahuasca extract also highlights the lack of systematic side-effect assessment, which is not mentioned in the other sources.