Post-dose follow-up, safety monitoring, and retention support

The manuals converge on the need for active post-dose contact rather than passive discharge. Across MDMA, psilocybin, LSD, ayahuasca, ibogaine, ketamine, and 5-MeO-DMT materials, the common pattern is scheduled follow-up calls or visits, checking physical and emotional state, reviewing adverse events or symptom change, and keeping participants aware of how to reach the team between sessions. Several sources also link follow-up to retention, with repeated contact attempts, reminder systems, and flexible or remote check-ins to keep people engaged through the study period. Sources differ mainly in the intensity and duration of follow-up. Some manuals focus on the first hours or days after dosing, such as daily calls for a week, 12 and 24 hour check-ins, or day 1, day 2, and day 7 assessments. Others extend monitoring for weeks, months, or even years, including 12 month, 6 month, and long-term follow-up. They also differ in emphasis, with some stressing safety surveillance for delayed distress, suicidality, insomnia, or medical issues, while others place more weight on integration, aftercare coordination, referral, and continuity with external clinicians or ordinary life.