Client preparation and therapeutic set/setting

The manuals converge on preparing a private, quiet, comfortable, low-stimulation setting that supports inward focus and safety. Across the extracts, the room is described as interruption-free, welcoming, and conducive to inner work, with practical comforts such as reclining or lying-down furniture, pillows, blankets, temperature control, and, in several manuals, music, eyeshades, water, and snacks.

Several sources also treat the physical environment as part of the therapeutic intervention rather than a neutral backdrop.

They also converge on advance preparation of the participant for what the session will involve. The manuals recommend orienting the person to the session structure, clarifying expectations, and discussing likely effects or concerns before dosing. Some sources add explicit preparation around rules and logistics, such as food, liquids, caffeine, nicotine, psychoactive substances, companion involvement, and overnight arrangements. The main differences are in emphasis and detail. The MDMA manuals and the LSD handbook place more weight on safe containment, visible medical readiness, secure storage, and practical room management for possible distress or movement, while the psilocybin and ayahuasca manuals emphasise a warm, inviting, living-room-like atmosphere and calming decor. The ketamine extract is more specific about supporting an internalised experience with an eye-mask and headphones, while the MDMA and LSD sources more often mention art supplies, video equipment, durable furnishings, or nearby washroom facilities.