Therapeutic Advances in Chronic Disease

Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review

This review (2014) examines ketamine as a prospective treatment option for patients with depression and provides an overview of its role within the glutamate system, its antidepressant mechanisms of action, safety profile, and evidence from clinical studies that investigated the efficacy of single or multiple infusions. Furthermore, it compares alternative modes of ketamine administration and highlights fundamental research on other types of NMDA agonists that may have less psychotomimetic effects.

Published

April 13, 2015

Journal

Therapeutic Advances in Chronic Disease

Authors

Iadarola, N. D., Niciu, M. J., Richards, E. M., Vande Voort, J. L., Ballard, E. D., Lundin, N. B., Nugent, A. C., Machado-Vieira, R., Zarate, C. A.