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Neuropsychopharmacology

70 Papers Indexed in Blossom

Data updated

Research Footprint

Neuropsychopharmacology has 70 tracked papers indexed in Blossom (1996–2026) from 397 authors, most often covering MDMA, LSD and Psilocybin, across Healthy Volunteers, Depressive Disorders and Anxiety Disorders.

Published Papers

Open Accessindividual

Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study

This randomised crossover trial (n=45) in healthy adults found that 100 µg LSD improved motor learning the next day and was linked to lower perceived stress and better cognitive flexibility one week later. It also changed EEG and TMS measures of brain activity, but did not alter BDNF levels.

Published
Journal
Neuropsychopharmacology
Authors
Calder, A. E., Diehl, V. J., Lietz, M. P., Yousefi, P., Friedli, N., Coviello, F., Rouaud, A., Beichmann, K., Eckert, A., Hasler, G.
Open Accessindividual

Acute dose-dependent effects of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) compared with 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin in a double-blind, placebo-controlled study in healthy participants

This double-blind, randomised, placebo-controlled crossover study (n=24) in healthy adults compared acute effects of 2C-B, MDMA and psilocybin. A 30 mg dose of 2C-B produced effects similar to MDMA and some psychedelic changes, while MDMA caused the strongest cardiovascular stimulation and psilocybin caused more anxiety and unpleasant effects.

Published
Journal
Neuropsychopharmacology
Authors
Arikci, D., Borgulya, J., Straumann, I., Vizeli, P., Luethi, D., Thomann, J., Rudin, D., Vukalovic, I., Eckert, A., Liechti, M. E., Holze, F.
Paywallindividual

Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity

This preclinical rat study (n=24; 8 rats per group) shows that a single dose of psilocybin (1.0 mg/kg) or the selective 5-HT2A receptor agonist 25CN-NBOH (1.5 mg/kg) reduces immobility in the forced-swim test, with effects persisting for at least three months. Electrophysiology of medial prefrontal cortex (mPFC) Layer 5 neurons reveals long-lasting functional, but not structural, plasticity—characterised by changes in resting membrane potential, neuronal firing rates, and excitatory synaptic input. In contrast, dendritic spine density and gene-expression markers related to synaptic structure remain unchanged, indicating enduring functional alterations rather than persistent structural modifications.

Published
Journal
Neuropsychopharmacology
Authors
Kramer, H. M., Hibicke, M., Middleton, J., Jaster, A. M., Kristensen, J. L., Nichols, C. D.
Open Accessindividual

Microdosing psychedelics and its effect on creativity: Lessons learned from three double-blind placebo controlled longitudinal trials

This combined analysis (n=175) of three double-blind placebo-controlled longitudinal experiments investigated the effects of microdosing psilocybin (0.74 -; 1.71mg) on creativity and found that it increased the originality of their ideas while generating novel applications for ordinary things (divergent thinking). However, it did not increase the number of novel ideas, or their ability to detect features that are common across multiple things (convergent thinking).

Published
Journal
Neuropsychopharmacology
Authors
Prochazkova, L., van Elk, M., Marschall, J., Rifkin, B. D., Fiacchino, D., Fejer, G., Hommel, B., Schoen, N.
Open Accessindividual

Acute effects of MDMA, MDA, lysine-MDMA, and lysine-MDA in a randomized, double-blind, placebo-controlled, crossover trial in healthy participants

In a randomized, double-blind, placebo-controlled crossover in 23 healthy volunteers, MDA produced longer‑lasting, stronger and more psychedelic‑like subjective and autonomic effects and more adverse reactions than equimolar MDMA. Lys‑MDA acted as a functional slow‑release prodrug that delayed onset and peak effects, whereas Lys‑MDMA did not release MDMA and produced no measurable effects, showing lysine conjugation can alter timing but not necessarily improve tolerability.

Published
Journal
Neuropsychopharmacology
Authors
Straumann, I., Vizeli, P., Avedisian, I., Erne, L., Noorshams, D., Vukalovic, I., Eckert, A., Luethi, D., Rudin, D., Liechti, M. E.
Open Accessindividual

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences

This neuroscience secondary (n=25) of two earlier studies used connectome harmonic decomposition to analyse how DMT affects brain function across the structural connectome (white matter pathways), finding that DMT reshapes the connectome harmonic repertoire and increases repertoire entropy similarly to other psychedelics (psilocybin, LSD, ketamine), and importantly demonstrating for the first time that energy spectrum differences and repertoire entropy measures correlate with subjective experience intensity in a time-resolved manner, revealing close coupling between connectome harmonics and conscious experience under psychedelics.

Published
Journal
Neuropsychopharmacology
Authors
Vohryzek, J., Luppi, A. I., Atasoy, S., Deco, G., Carhart-Harris, R. L., Timmermann, C., Kringelbach, M. L.

Quick Facts

Papers Indexed
70
h-Index
258
Open Access
No
Publisher
Nature Portfolio
Country
Switzerland
Website
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