In 49 inpatients with treatment‑resistant depression receiving eight 0.5 mg/kg IV ketamine infusions, dissociative symptoms showed significant transient increases (CADSS; P = .003) while psychomimetic symptoms (BPRS) did not significantly change, and both returned to “absent” within one hour and were not associated with treatment outcome. The results suggest a favourable acute safety profile for ketamine as an adjunct to standard pharmacotherapy, although the small, unblinded observational design limits power and causal inference.
- Published
- Journal
- Medicine
- Authors
- Cubała, W. J., Szarmach, J., Galuszko-Wegielink, M., Wlodarczyk, A.