In 323 patients with treatment‑resistant depression, self‑reported improvements in insomnia, night‑time restlessness, early morning waking and overall sleep partially mediated the antidepressant and anti‑suicidal effects of four IV ketamine infusions. Except for hypersomnia, better sleep was also linked to higher likelihood of response/remission — each one‑point improvement in total sleep score tripled the odds of responder/remitter status (OR 3.29, 95% CI 2.00–5.41).
- Published
- Journal
- Journal of Sleep Research
- Authors
- Rodrigues, N. B., Mcintyre, R. S., Lipsitz, O., Cha, D. S., Cao, B., Lee, Y., Gill, H., Lui, L. M. W., Wiesław, |., Cubała, J., Ho, R., Shekotikhina, M., Teopiz, K. M., Subramaniapillai, |. M., Kratiuk, K., Mansur, R. B., Rosenblat, J. D.