Back to journals
Academic JournalOpen Access

International Journal of Molecular Sciences

2 Papers Indexed in Blossom

Data updated

Research Footprint

International Journal of Molecular Sciences has 2 tracked papers indexed in Blossom (2022) from 19 authors, most often covering Ketamine, Psilocybin and MDMA, across Depressive Disorders, Anxiety Disorders and Medicinal Chemistry & Drug Development.

Published Papers

Open Accessindividual

Methylone and MDMA Pharmacokinetics Following Controlled Administration in Humans

In a first controlled human study, oral methylone (50–200 mg) showed rapid, dose‑proportional (linear) pharmacokinetics with Cmax and AUC increasing proportionally, Tmax ≈1.5–2 h and t1/2 ≈6–7 h. A validated LC–MS/MS assay quantified methylone, MDMA and metabolites and found the primary metabolite HMMC had much lower exposure (Cmax ~10–14× and AUC ~21–29× lower) and faster kinetics than the parent drug.

Published
Journal
International Journal of Molecular Sciences
Authors
Poyatos, L., Lo Faro, A., Sprega, G., Malaca, S., Pichini, S., Huestis, M. A., Papaseit, E., Busardo, F., Farré, M., Beradinelli, D., Perez-Castillo, A.
Open Accessindividual

Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior

A single dose of ketamine (10 mg/kg) or psilocybin (2 and 10 mg/kg) in rats acutely increased extracellular dopamine, serotonin, glutamate and GABA in the frontal cortex (psilocybin also raised GABA in the thalamic reticular nucleus), induced oxidative DNA damage (psilocybin in frontal cortex; both drugs in hippocampus) and upregulated the NR2A glutamate receptor subunit after high-dose psilocybin. These neurochemical and genotoxic changes occurred without detectable antidepressant or anxiolytic behavioural effects 24 h later, although ketamine reduced locomotor activity.

Published
Journal
International Journal of Molecular Sciences
Authors
Wojtas, A., Bysiek, A., Wawrzczak-Bargiela, A., Szych, Z., Majcher-Maslanka, I., Herian, M., Mackowiak, M., Golembiowska, K.

Quick Facts

Papers Indexed
2
h-Index
314
Open Access
Yes
Publisher
MDPI
Country
Switzerland
Website
Visit