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Clinical and Translational Science

2 Papers Indexed in Blossom

Data updated

Research Footprint

Clinical and Translational Science has 2 tracked papers indexed in Blossom (2022–2025) from 15 authors, most often covering DMT, across Healthy Volunteers, Medicinal Chemistry & Drug Development and Depressive Disorders.

Published Papers

Open Accessindividual

Safety, Pharmacokinetics, and Pharmacodynamics of a 6-h N,N-Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial

This randomized, double‑blind, placebo‑controlled study found that a 30‑s bolus followed by a 6‑hour intravenous DMT infusion (maximal exposures ≈35 ng/mL) was well tolerated in healthy volunteers with no serious adverse events and only mild, rapidly occurring psychedelic effects. Moderate interindividual pharmacokinetic variability was observed and the highest dose produced transient reductions in sustained attention, postural stability and occipital alpha power, providing a safety and PK/PD basis for future proof‑of‑mechanism studies in patient populations.

Published
Journal
Clinical and Translational Science
Authors
Zuiker, R. G. J. A., Otto, M. E., Bryan, C. S., Stewart, N., Stillwell, C., de Kam, M. L., van Leuken, M. B., van Gerven, J. M. A., Jacobs, G. E., van der Heijden, K. V.
Open Accessindividual

Population pharmacokinetic/pharmacodynamic modelling of the psychedelic experience induced by N,N-dimethyltryptamine - implications for dose considerations

Using data from 13 healthy volunteers given intravenous DMT, the authors developed a population PK/PD model (two‑compartment PK, high clearance ≈26 L/min, effect‑site sigmoid Emax with EC50 ≈95 nM) linking plasma concentrations to subjective psychedelic intensity. Simulations translate exposure into dose–response predictions (median maximum intensity ratings for 1–20 mg), providing a tool to guide dose selection in clinical investigations.

Published
Journal
Clinical and Translational Science
Authors
Eckernäs, E., Timmermann, C., Carhart-Harris, R., Röshammar, D., Ashton, M.

Quick Facts

Papers Indexed
2
h-Index
65
Open Access
Yes
Publisher
Wiley
Country
United Kingdom
Website
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