Independent outcome assessment administration

The manuals converge on the need for structured, unbiased outcome assessment. Across the extracts, they emphasise keeping patient-rated and clinician-rated measures separate, preserving independence between roles, and coordinating assessments in a way that supports accurate data collection. Several sources also stress consistency across contacts and time points, whether assessments are done in person or by telephone, and one source explicitly notes that patient-rated and clinician-rated assessments are completed independently and without reference to each other. They also overlap in treating assessment order and role clarity as part of trial integrity. One manual specifies that QIDS-SR-16 is administered first and checked for completeness, while another highlights maintaining a neutral atmosphere for patient-completed scales. The ayahuasca trial and the LSD protocol both frame separation of supportive or therapist roles from outcome-rating roles as important, and the ayahuasca source adds that who performed each role should be documented. The manuals differ mainly in level of detail and emphasis. The ibogaine manual is the most operational, listing specific instruments, reading items aloud when required, and collecting written or recorded descriptions when indicated. By contrast, the ketamine, ayahuasca, and LSD sources focus more on role separation, independence, and minimising bias, with less detail about the mechanics of administering individual measures.