Controlled-substance handling awareness

The manuals converge on the need for strict controlled-substance accountability for investigational psychedelics and related agents. Across the extracts, they describe secure storage, limited access, supervised administration, accurate documentation, and clear chain-of-custody or inventory procedures as central to compliant handling. They also consistently frame these drugs as requiring regulatory control, with records such as logs, labeling, and accountability documentation kept in order. The sources differ mainly in the operational details they emphasise. The MDMA manuals focus on supervised research administration, no take-home doses, restricted storage, and keeping the drug on premises, while the ketamine manual highlights temperature control, protection from light, and inventory, transfer, and usage logs. The psilocybin protocol places more emphasis on authorised personnel, secure transport in approved containers, separation from non-study drugs, and reporting accountability discrepancies to the DEA, so the exact handling requirements vary by substance and study context.