This Third Wave article explores ketamine therapy as an emerging approach for anxiety and related mood disorders. It outlines the limits of common treatments such as SSRIs and benzodiazepines, and summarizes why some clinicians are looking at ketamine as an alternative within a broader treatment plan. The piece explains ketamine’s proposed mechanism in the brain, with attention to glutamate and neuroplasticity rather than the usual serotonin model. It also describes how guided ketamine therapy and integration counseling may be used to support the therapeutic process. The content is aimed at readers interested in psychedelic-assisted therapy, especially those seeking a clear overview of ketamine’s potential role in mental health care. It is presented as a written educational article rather than a formal training program.