Sub-Anaesthetic Ketamine at C-Section to Prevent Postpartum Depression: Double-Blind RCT (Alipoor / Sarkoohi, Rafsanjan Iran 2021)
This unregistered trial (n=134) was a double-blind, placebo-controlled randomised clinical trial of sub-anaesthetic ketamine for the prevention of postpartum depression in women undergoing elective caesarean sections, which found that ketamine significantly reduced depression scores at two and four weeks postpartum.
Detailed Description
This synthetic trial has been added to our database because a psychedelic paper (about a clinical trial) references this trial, but no (live) registration can be found.
The study evaluated the efficacy of a single sub-anaesthetic dose of intravenous ketamine (0.5 mg/kg) administered during the induction of general anaesthesia for elective caesarean sections. Participants were randomised to receive either ketamine alongside a sedative or a higher dose of sedative alone as a control.
The primary outcome was measured using the Edinburgh Postnatal Depression Scale (EPDS) at two and four weeks following delivery. Results indicated that the ketamine intervention group exhibited significantly lower depression scores compared to the control group at both follow-up intervals, suggesting a potential preventative effect against postpartum depression.
Study Protocol
Preparation
Dosing
Integration
Study Arms & Interventions
Ketamine-Nesdonal group
experimentalNesdonal 1-2 mg/kg plus ketamine 0.5 mg/kg IV during anesthesia induction for caesarian section.
Interventions
- Ketamine0.5 mg/kgvia IV• single dose during anesthesia induction• 1 doses total
Sub-anesthetic ketamine dose administered with Nesdonal during induction of general anesthesia.
Nesdonal group
active comparatorNesdonal 3-5 mg/kg IV during anesthesia induction for caesarian section.
Study Details
- StatusCompleted
- Typeinterventional
- DesignRandomizeddouble Blind
- Target Enrollment134 participants
- TimelineStart: 2019-01-01End: 2021-01-01
- Compound
- Topic