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Long-term efficacy of psilocybin with adjunct psychotherapy in treatment-resistant depressionPsilocybin · Treatment-resistant depressionDrug-drug interactions between psychiatric medications and MDMA or psilocybinMDMA & psilocybin · SafetyAn international mega-analysis of psychedelic drug effects on brain circuit functionCross-compound · NeuroimagingEsketamine in treatment-resistant depression with and without comorbid borderline personalityEsketamine · Treatment-resistant depression

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Government direct investments, R&D tax credits, and incentive programmes for psychedelic medicine development.

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Defense Advanced Research Projects Agency (DARPA)

US defense research funder with psychedelic-informed neuropsychiatric R&D (Focused Pharma).

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US Advanced Research Projects Agency for Health (ARPA-H)

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ARPA-H is the US federal agency for high-risk, high-reward biomedical research. Launched the EVIDENT initiative in 2025 (total $139.4M, ≥$50M earmarked for psychedelic research for serious mental illness) to validate and innovate behavioral-health therapeutics including psilocybin and related compounds.

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