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Research/Ketamine for Depressive Disorders/Adverse events
Curated safety summary

Ketamine for Depressive Disorders: adverse events

Ketamine safety reports for Depressive Disorders most often include dizziness, headache, nausea, paresthesia among the source-backed named adverse events currently normalized in Blossom.

Papers with named AEs
26
Named AE rows
278
Source papers
161
Residual papers
135

How to read this summary

This page summarizes named adverse-event rows extracted from published paper, supplement, and registry evidence. It is intended as an evidence navigation aid and should not be read as a formal pharmacovigilance estimate or direct cross-trial comparison.

Most commonly reported named events

Counts are aggregated from source-backed named adverse-event rows. Denominators are shown only where the source row reported or clearly inherited one.

Back to evidence set →
EventAggregate countRatePapersSource terms
dizziness1031/878211.7%14Dizziness, Dizzy, Vertigo
headache741/475715.6%18Headache, Headaches, headache, headaches
nausea650/291422.3%16Nausea, nausea
paresthesia499/72006.93%3Hypoaesthesia, Paraesthesia
dissociation474/215722%7Dissociation, dissociation
nasal discomfort407/329712.3%4Nasal Discomfort, Nasal congestion, Nasopharyngitis
dysgeusia331/215715.3%3Dysgeusia
somnolence324/220014.7%4Sleepiness, Somnolence
anxiety298/37407.97%11Anxiety
blood pressure increased295/35428.33%7Blood Pressure Increased, Blood pressure increased, Hypertension, increased blood pressure
fatigue267/35317.56%12Fatigue, fatigue
vomiting239/27808.60%8Vomiting

dizziness

dizziness was captured in 14 source papers (1031/8782). Interpret this as a source-backed named-event summary, not a head-to-head safety comparison.

Esketamine Nasal Spray|365/1110| 32.9%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Dizziness 365/1110 (32.9%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|198/1110| 17.8%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Vertigo 198/1110 (17.8%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|95/458| 20.7%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Dizziness 95/458 (20.7%) in Esketamine Nasal Spray (IND Phase).

Esketamine Nasal Spray|77/458| 16.8%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Vertigo 77/458 (16.8%) in Esketamine Nasal Spray (IND Phase).

headache

headache was captured in 18 source papers (741/4757). Interpret this as a source-backed named-event summary, not a head-to-head safety comparison.

Esketamine Nasal Spray|401/1110| 36.1%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Headache 401/1110 (36.1%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|70/458| 15.3%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Headache 70/458 (15.3%) in Esketamine Nasal Spray (IND Phase).

Placebo + Standard of care|26/113| 23%| during treatment
Effects of esketamine on patient-reported outcomes in major depressive disorder with active suicidal ideation and intent: a pooled analysis of two randomized phase 3 trials (ASPIRE I and ASPIRE II)
registry:effects-of-esketamine-on-patient-reported-outcomes-in-major-depressive-disorder-:NCT03097133:ctg-api

ClinicalTrials.gov adverse events: Headache 26/113 (23%) in Placebo + Standard of Care (SOC).

Esketamine 84 mg|24/121| 19.8%| during treatment
Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial
registry:esketamine-monotherapy-in-adults-with-treatment-resistant-depression-a-randomize:NCT04599855:ctg-api

ClinicalTrials.gov adverse events: Headache 24/121 (19.8%) in DB: Esketamine 84 mg.

nausea

nausea was captured in 16 source papers (650/2914). Interpret this as a source-backed named-event summary, not a head-to-head safety comparison.

Esketamine Nasal Spray|356/1110| 32.1%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Nausea 356/1110 (32.1%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|82/458| 17.9%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Nausea 82/458 (17.9%) in Esketamine Nasal Spray (IND Phase).

Esketamine 84 mg|32/121| 26.4%| during treatment
Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial
registry:esketamine-monotherapy-in-adults-with-treatment-resistant-depression-a-randomize:NCT04599855:ctg-api

ClinicalTrials.gov adverse events: Nausea 32/121 (26.4%) in DB: Esketamine 84 mg.

Esketamine 56 mg|24/105| 22.9%| during treatment
Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial
registry:esketamine-monotherapy-in-adults-with-treatment-resistant-depression-a-randomize:NCT04599855:ctg-api

ClinicalTrials.gov adverse events: Nausea 24/105 (22.9%) in DB: Esketamine 56 mg.

paresthesia

paresthesia was captured in 3 source papers (499/7200). Interpret this as a source-backed named-event summary, not a head-to-head safety comparison.

Esketamine Nasal Spray|102/1110| 9.20%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Hypoaesthesia 102/1110 (9.2%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|92/1110| 8.30%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Paraesthesia 92/1110 (8.3%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|83/1110| 7.50%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Hypoaesthesia Oral 83/1110 (7.5%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|69/1110| 6.20%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Paraesthesia Oral 69/1110 (6.2%) in Esketamine Nasal Spray (OP/MA Phase).

dissociation

dissociation was captured in 7 source papers (474/2157). Interpret this as a source-backed named-event summary, not a head-to-head safety comparison.

Esketamine Nasal Spray|272/1110| 24.5%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Dissociation 272/1110 (24.5%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|100/458| 21.8%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Dissociation 100/458 (21.8%) in Esketamine Nasal Spray (IND Phase).

Esketamine 84 mg|32/121| 26.4%| during treatment
Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial
registry:esketamine-monotherapy-in-adults-with-treatment-resistant-depression-a-randomize:NCT04599855:ctg-api

ClinicalTrials.gov adverse events: Dissociation 32/121 (26.4%) in DB: Esketamine 84 mg.

Esketamine 56 mg|23/105| 21.9%| during treatment
Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial
registry:esketamine-monotherapy-in-adults-with-treatment-resistant-depression-a-randomize:NCT04599855:ctg-api

ClinicalTrials.gov adverse events: Dissociation 23/105 (21.9%) in DB: Esketamine 56 mg.

nasal discomfort

nasal discomfort was captured in 4 source papers (407/3297). Interpret this as a source-backed named-event summary, not a head-to-head safety comparison.

Esketamine Nasal Spray|267/1110| 24.1%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Nasopharyngitis 267/1110 (24.1%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|93/1110| 8.40%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Nasal Discomfort 93/1110 (8.4%) in Esketamine Nasal Spray (OP/MA Phase).

Esketamine Nasal Spray|23/458| 5%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Nasal Discomfort 23/458 (5%) in Esketamine Nasal Spray (IND Phase).

Esketamine Nasal Spray|13/458| 2.80%| during treatment
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
registry:efficacy-and-safety-of-esketamine-nasal-spray-in-patients-with-treatment-resista:NCT02782104:ctg-api

ClinicalTrials.gov adverse events: Nasopharyngitis 13/458 (2.8%) in Esketamine Nasal Spray (IND Phase).

Limitations

  • Counts are aggregated from source-backed named adverse-event rows and may mix event windows, arms, and safety populations when papers report them differently.
  • Papers still in the named-AE residual blocker queue are not interpreted as event absence.
  • Denominators are included only when the source row reported or clearly inherited one.
  • This summary is a curated navigation layer, not a substitute for paper-level safety review.

Source papers

Protocol and pilot results for a double-blind randomized placebo-controlled trial of ketamine under propofol sedation for chronic pain and depression
Pain Management | 2026
Single dose IV ketamine for adolescent suicidal ideation in the emergency department: a pilot randomized trial
BMC Psychiatry | 2026
Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD A Randomized Clinical Trial
JAMA Psychiatry | 2026
Effect of Esketamine on Depressive Symptoms in Adolescents with Major Depressive Disorder at Imminent Suicide Risk: A Randomized Psychoactive-Controlled Study
Journal of the American Academy of Child & Adolescent Psychiatry | 2026
Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial
JAMA Psychiatry | 2025
Safety and Efficacy with Esketamine in Treatment-Resistant Depression: Long-Term Extension Study
International Journal of Neuropsychopharmacology | 2025
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
CNS Drugs | 2023
Effects of esketamine on patient-reported outcomes in major depressive disorder with active suicidal ideation and intent: a pooled analysis of two randomized phase 3 trials (ASPIRE I and ASPIRE II)
Quality of Life Research | 2023
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression
New England Journal of Medicine | 2023
Adjunctive Ketamine With Relapse Prevention-Based Psychological Therapy in the Treatment of Alcohol Use Disorder
American Journal of Psychiatry | 2022
Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial
Neuropsychopharmacology | 2022
This Is Something That Changed My Life: A Qualitative Study of Patients' Experiences in a Clinical Trial of Ketamine Treatment for Alcohol Use Disorders
Frontiers in Psychiatry | 2021