Clinical Hemorheology and Microcirculation

Hemorheological and metabolic consequences of renal ischemia-reperfusion and their modulation by N,N-dimethyl-tryptamine on a rat model

Renal ischaemia–reperfusion in rats causes metabolic disturbance (raised lactate, acidosis) and adverse micro-rheological changes (increased erythrocyte aggregation, reduced deformability). Pre‑treatment with the sigma‑1 receptor agonist N,N‑dimethyltryptamine attenuated but did not fully prevent these metabolic and micro‑rheological alterations.

Published

April 13, 2018

Journal

Clinical Hemorheology and Microcirculation

Authors

Peto, K., Nemeth, N., Mester, A., Magyar, Z., Ghanem, S., Somogyi, V., Tanczos, B., Deak, A., Bidiga, L., Frecska, E., Nemes, B.