American Journal of Physiology

Serotonin 5-HT2 receptor activation prevents allergic asthma in a mouse model

This mouse study investigated the effects of the highly selective 5-HT₂ receptor agonist (R)-DOI (0.01-1mg/kg) in a mouse model of allergic asthma. They demonstrate that inhaled (R)-DOI has potent anti-inflammatory effects and blocks the development of allergic asthma through the activation of the serotonin 5-HT2A receptor subtype.

Published

January 15, 2015

Journal

American Journal of Physiology

Authors

Nau, F., Miller, J., Saravia, J., Ahlert, T., Yu, B., Happel, K. I., Cormier, S. A., Nichols, C. D.