This advanced program covers precision medicine-based ketamine therapy, target-controlled infusion methodology, pharmacokinetics, individualized dosing, genetic and laboratory-guided adjustments, adverse-effect mitigation, and patient safety. It includes evidence-based didactics, supervised clinical experience, and a supervised personal ketamine infusion to support a patient-centered understanding of treatment. The program is designed for clinicians seeking to establish or optimize ketamine therapy services, including MDs, DOs, NPs, and CRNAs. Participants receive protocols, evaluation templates, safety checklists, standard operating procedures, and a pharmacokinetic dosing calculator. The practical component consists of three intensive days at the institute's infusion center, followed by 12 months of clinical consultations, business guidance, and mentorship. Graduates earn KRI certification and are listed in the institute's national clinician directory.